Monday January 18, 2010

Q: The Claviprex (clevidipine butyrate) is a newly approved IV medication for acute hypertension control as a continuous infusion. It is relatively contraindicated in patients with?

A) Allergies to soybeans, soy products, eggs, or egg products;
B) Defective lipid metabolism such as pathologic hyperlipemia, lipoid nephrosis,
C) Acute pancreatitis if it is accompanied by hyperlipidemia;
D) Severe aortic stenosis.
E) All of the above


Answer: E

It is a lipid based drug. It is almost look alike Propofol at bedside (care should be taken in titrating due to accidental confusion). It contains phospholipids and can support microbial growth. Once the stopper is punctured, it should be use and discarded within 4 hours.

It has an extremely short half life of 90 seconds and desirable for close titration of hypertension.